Ferritin,an iron storage protein naturally occurring in the body,has emerged as a promising nanocarrier thanks to its unique architecture,excellent biocompatibility,and ability to self-assemble/disassemble (Fan et al.,2013).More specifically,the finding that human H-ferritin intrinsically targets tumor cells via binding to its receptor transferrin receptor 1 (TfR1) (Li et al.,2010;Fan et al.,2012;Liang et al.,2014;Zhao et al.,2016) inspired research into using ferritins for tumor target therapy.