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目的 探讨中国北方汉族人主要组织相容性复合体(Major Histocmpatibitity Complex,MHC)基因多态性与衰老的相关性。方法 应用补体依赖的微量淋巴细胞毒技术,检测了对照组、长寿组和少年组健康人的MHC—A、B、C抗原基因,统计比较各组的抗原基因的频率。结果 MHC—A1等位基因在长寿组中较对照组明显增高(RR=6.07 P<0.01)呈正相关,而MHC—C3等位基因则明显降低(RR=18.5 P<0.01),呈负相关。结论 MHC—A1等位基因或其连锁基因可能是北方汉族人的长寿基因。该基因可能具有某种生物学优势,在抵抗疾病和保护正常生命活动中起一定作用。而MHC一C3等位基因则相反,称衰老基因。
Objective To investigate the association of major histocompatibility complex (MHC) gene polymorphism with aging in Chinese Han population in northern China. Methods The MHC-A, B and C antigen genes of control group, longevity group and juvenile group were detected by complement-dependent microlymphocytotoxicity. The frequencies of antigenic genes in each group were statistically compared. Results The allele of MHC-A1 was positively correlated with that of the control group (RR = 6.07 P <0.01), while the MHC-C3 allele was significantly decreased (RR = 18.5 P <0.01) in the longevity group. Conclusion The MHC-A1 allele or its linkage gene may be a longevity gene in northern Han Chinese. This gene may have some biological advantage that plays a role in fighting disease and protecting normal life activities. The MHC-C3 allele is the opposite, said the aging gene.