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目的探讨性早熟对2~10岁女童骨密度的影响。方法选择2003-01—2006-01在湖南省儿童医院内分泌专科就诊的2~10岁性早熟(明确诊断、并排除影响骨代谢性疾病)女童237例,根据真、假性性早熟(CPP、PPP)分为2组,各组再按年龄组分层,采用单光子骨矿物质密度测定仪测量左手桡骨中远1/3处桡、尺骨密度(BMD),并与同龄健康女童进行对比和分析。结果CPP、PPP和健康组BMD均随年龄增长而增加,3组各年龄桡骨BMD均高于尺骨;CPP桡、尺骨BMD均相对较高,8~10岁组中CPP较对照组约高6.4%~8.6%;3组桡、尺骨BMD均在8~10岁增长加速,特别是尺骨(P<0.05),分别较6~7岁组增长20.4%、17.8%和14.3%;以CPP组增幅最大,明显高于健康组,与健康组(6~7岁)增长比较差异有显著性(桡骨P<0.05、尺骨P<0.001)。PPP组则与健康女童差异不显著。结论健康女童骨矿化自9岁起开始青春期加速,CPP女童青春期尺骨生长加速的年龄提早,BMD相应增加,而PPP不像CPP那样明显影响女童的正常骨骼发育。
Objective To investigate the effect of precocious puberty on bone mineral density in girls aged 2 ~ 10 years. Methods A total of 237 girls with precocious puberty (2 ~ 10 years old diagnosed and excluded from the bone metabolic disease) were selected from Department of Endocrinology, Children’s Hospital of Hunan Province from January 2003 to January 2006. According to the results of true and false precocious puberty (CPP, PPP) were divided into two groups. Each group was further grouped according to age group. The radial and ulnar bone mineral density (BMD) in the middle and far 1/3 of the left hand radius were measured by single photon bone mineral density meter, and compared with healthy girls of the same age . Results The BMD of CPP, PPP and healthy group increased with age. The BMD of radius in all three groups was higher than that of ulna. The radial and ulnar BMD of CPP were relatively high, and CPP in 8-10 years old group was 6.4% higher than that of control group ~ 8.6% respectively. The BMD of radial and ulnar in all three groups accelerated at the age of 8 to 10 years, especially in ulna (P <0.05), increasing by 20.4%, 17.8% and 14.3% , Significantly higher than that in healthy group (P <0.05 in radius and P <0.001 in ulna) compared with healthy group (6-7 years old). PPP group and healthy girls was not significantly different. CONCLUSIONS: Bone mineralization in healthy girls began to accelerate from adolescence at 9 years of age. The age of adolescent osteopod growth was earlier and the BMD increased correspondingly. However, PPP did not affect the normal skeletal development of girls as CPP did.