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对我们研究小组近几年在Lewis碱催化具有α-位氢的α-胺基腈类及氰醇类化合物与Morita-Baylis-Hillman(MBH)加合物立体选择性的烯丙基化反应方面取得的初步成果进行了小结.通过与MBH加合物的烯丙基取代反应,有效地构建了具有α-位季碳结构单元的多官能团腈类衍生物,而且基于此发展了一类非金属催化的烯烃分子内氰官能团化反应,构建了β-位有季碳结构单元的官能团化的腈类化合物.此外对影响反应的可能因素也做了讨论,提出了可能的反应机理.
In recent years, our research team has made some progress in Lewis stereoselective stereospecific allylation of α-aminonitriles and cyanohydrin compounds with Morita-Baylis-Hillman (MBH) adduct The preliminary results obtained are summarized.Multifunctional nitrile derivatives possessing α-position quaternary carbon structural units are effectively constructed by allylic substitution reaction with MBH adduct, and based on this, a class of nonmetal Catalyzed cyano functionalization in alkene molecules to form functionalized nitrile compounds with β-position quaternary carbon structural units.In addition, the possible factors affecting the reaction were also discussed, and the possible reaction mechanism was proposed.