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目的比较苍白密螺旋体或风疹病毒、巨细胞病毒、单纯疱疹病毒(RCH)在孕妇母婴垂直传播概率。方法对近年来医院所有患者中苍白密螺旋体感染情况和4303例进行RCH检测的孕妇进行回顾性分析,并对34例RCH抗体IgM阳性的孕妇和22例孕中晚期苍白密螺旋体阳性孕妇进行经腹脐静脉穿刺后,抽取胎儿血进行检测。结果胎传梅毒感染成逐年上升趋势,而3708例正常孕妇中RCH中一项IgM抗体的47例,阳性率为1.26%,明显低于流产组患者(2.46%)、死胎组(5.26%)及胎儿畸形组(28.54%);在34例RCH IgM抗体阳性的孕妇中,胎儿血中只有1例HSV-IgM呈阳性,随访未发现新生儿异常;在22例梅毒阳性患者中,7例胎儿RPR,TPHA均为阳性;15例胎儿为RPR阴性,TPHA阳性。结论苍白密螺旋体感染比RCH更容易造成宫内感染。
Objective To compare the probability of vertical transmission between mother and baby in Tremolo Treponema or rubella virus, cytomegalovirus and herpes simplex virus (RCH). Methods A retrospective analysis was performed on the prevalence of Treponema pallidum in 4303 patients with RCH detected in all the hospitalized patients in recent years. Twenty-four pregnant women with RCH IgM positive and 22 pregnant women with Treponema pallidum Umbilical vein puncture, extraction of fetal blood for testing. Results The rate of fetal syphilis increased year by year. The positive rate of one IgM antibody in RCH of 3708 pregnant women was 1.26%, which was significantly lower than that of miscarriage patients (2.46%), stillbirths patients (5.26%) and Fetal deformity group (28.54%). Of the 34 RCH IgM antibody-positive pregnant women, only one HSV-IgM was positive in fetus blood and no newborn abnormalities were found at follow-up. Of the 22 syphilis-positive patients, 7 , TPHA were positive; 15 cases of RPR-negative fetus, TPHA-positive. Conclusion Treponema pallidum infection is more likely to cause intrauterine infection than RCH.