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用神经节苷脂（ＧＭ１）（１０ｍｇ／ｋｇ）处理器血管闭塞全脑缺血再灌注模型，观察缺血海马组织线粒体钙（ＭｉｔｏｃｈｏｎｄｒｉａＣａｌｃｉｕｍ、ＭＣａ）钙调素（Ｃａｌｍｏｄｕｌｉｎ，ＣａＭ）的含量变化及评价ＧＭ１对其变化的影响。结果表明。ＧＭ１能遏止缺血再灌注期ＭＣａ、ＣａＭ含量明显增高的变化，明显减轻缺血再灌注期的钙跨膜内流，具有肯定的脑保护作用。
The changes of the content of calmodulin (CaM) and the content of mitochondrial calcium (MCM) in ischemic hippocampus were observed with GM1 (10mg / kg) The impact of GM1 on its changes. The results show. GM1 can curb the changes of MCa and CaM during ischemia-reperfusion, and obviously reduce the transmembrane infiltration of calcium during ischemia-reperfusion, which has positive brain protective effect.