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目的:探讨慢性肾功能不全致不宁腿综合征的临床特点,治疗方法及疗效。方法:对我院近4年收治的18例慢性神功能不全合并不宁腿综合症患者的临床特征和治疗结果进行回顾性分析。结果:所有患者均经常出现下肢难以形容的不适感、蚁走感、酸痛胀感而伴发腿部急促运动,静息时开始或加重,运动后缓解,夜间睡眠时加重,严重者可侵及上肢并引发夜间睡眠障碍这18例患者均确诊慢性肾功能不全5年以上,其中有12例长期接受血液透析。10例患者下肢肌电图检查显示神经传导速度减慢。8例血清铁的含量降低。给予神经营养剂、铁剂、多巴胺、笨二氮卓类镇静剂、血液透析及灌流,取得了良好的治疗效果。结论:不宁腿综合征目前发病机制不明,对慢性肾功能不全合并不宁腿综合征的患者应采用多种药物和血液透析及灌流相结合的综合治疗。
Objective: To investigate the clinical features, treatment and efficacy of restless legs syndrome with chronic renal insufficiency. Methods: A retrospective analysis was performed on the clinical features and treatment outcomes of 18 patients with chronic neurological deficiencies complicated with restless legs syndrome admitted to our hospital in recent 4 years. Results: All patients often have indefinable lower extremity discomfort, ants feel away, pain and swelling accompanied by rapid leg movement, rest or start to increase, remission after exercise, increased nighttime sleep, severe cases can be invading Upper extremity and lead to nighttime sleep disorders These 18 patients were diagnosed with chronic renal insufficiency for more than 5 years, of which 12 patients received long-term hemodialysis. Lower extremity EMG examination in 10 patients showed slowing of nerve conduction. 8 cases of serum iron content decreased. Given neurotrophic agents, iron, dopamine, stupid, nitazoxan sedation, hemodialysis and perfusion, and achieved good therapeutic effect. Conclusion: The current pathogenesis of restless legs syndrome is unknown. Patients with chronic renal insufficiency with restless legs syndrome should be treated with multiple drugs combined with hemodialysis and perfusion.