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目的探讨肺癌脑转移患者应用鸦胆子油联合放射治疗的临床疗效。方法选择该院2010年3月—2012年1月86例非小细胞肺癌脑转移瘤患者,按照随机分组的原则,分为治疗组44例,对照组42例。对照组采用单纯放射治疗(40Gy/20F/26d),治疗组采用放射治疗~+鸦胆子油乳,1次/d,每次30ml,30d为1个周期。比较二组患者临床改善情况、恶心呕吐、肝功能损害、肾功能损害等并发症发生情况,采用流式细胞计数仪分析比较二组患者治疗前后外周血中CD3~+、CD4~+、CD8~+、CD4I~+/CD8~+、NK细胞的含量。结果治疗组总有效率为79.5%,对照组总有效率为61.9%,差异有统计学意义(P<0.05);治疗组患者恶心呕吐发生比例显著低于对照组(P<0.05);治疗组CD4~+细胞比例、CD4~+/CD8~+比值、NK细胞比例均显著高于对照组(P<0.05),CD8~+细胞比例显著低于对照组(P<0.05)。结论与单纯放射治疗相比,肺癌脑转移患者应用鸦胆子油联合放射治疗临床疗效更好,并可降低并发症发生率,并提高患者免疫功能。
Objective To investigate the clinical effect of javanica combined with radiotherapy in patients with brain metastasis of lung cancer. Methods The hospital from March 2010 to January 2012 86 cases of non-small cell lung cancer patients with brain metastases, according to the principle of randomized divided into treatment group 44 cases, control group 42 cases. The control group was treated with radiotherapy alone (40Gy / 20F / 26d). The treatment group was treated with radiotherapy + Brucea javanica oil once, 30ml for 30 days and one cycle for 30 days. The changes of CD3 ~ +, CD4 ~ +, CD8 ~ + in peripheral blood in two groups before and after treatment were analyzed by flow cytometry comparing the clinical improvement, nausea and vomiting, liver dysfunction and renal dysfunction in the two groups. +, CD4I ~ + / CD8 ~ +, NK cell content. Results The total effective rate was 79.5% in the treatment group and 61.9% in the control group, the difference was statistically significant (P <0.05); the incidence of nausea and vomiting in the treatment group was significantly lower than that in the control group (P <0.05) The proportion of CD4 ~ + cells, the ratio of CD4 ~ + / CD8 ~ + and the proportion of NK cells were significantly higher than those of the control group (P <0.05). The percentage of CD8 ~ + cells was significantly lower than that of the control group (P <0.05). Conclusion Compared with simple radiotherapy, the application of Brucea javanica oil combined with radiotherapy in patients with brain metastasis of lung cancer has better curative effect, can reduce the complication rate and improve the immune function.