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给家兔喂饲胆固醇和疏氮(艹卓)酮,观察其血清和主动脉壁脂质及钙的含量,血液流变学变化和主动脉壁粥样硬化病变的程度。结果,硫氮(艹卓)酮组胆固醇和甘油三酯增加较对照组少(P<0.01),主动脉壁钙含量较对照组低,主动脉壁粥样硬化病变程度较对照组轻(P<0.01)。电镜下观察硫氮(艹卓)酮组的心肌超微结构,见心肌内毛细血管显著扩张,心肌细胞多较完整,无核周水肿,细胞受损较轻。对照组则相反,以上结果表明硫氮(艹卓)酮可能有降低血脂,阻止主动脉壁钙沉着,减轻或延缓主动脉粥样病变发生和对喂饲高胆固醇家兔的心肌起保护作用。
The rabbits were fed with cholesterol and nitrogen-removing ketones to observe the serum and aortic wall lipid and calcium levels, hemorheology changes, and aortic wall atherosclerotic lesions. Results: Compared with the control group, there was less increase in cholesterol and triglyceride levels in the sulfur-nitrogen group (P<0.01). The calcium content in the aortic wall was lower than in the control group, and the degree of atherosclerosis in the aortic wall was lighter than that in the control group (P). <0.01). The ultrastructure of myocardium in the sulphur-nitrogen group was observed under electron microscope. Capillary blood vessels in the myocardium were significantly expanded, myocardial cells were more complete, no perinuclear edema, and cell damage was lighter. In the control group, on the contrary, the above results suggest that sulfur-nitrogen may reduce blood lipids, prevent calcium deposition in the aortic wall, reduce or delay the occurrence of aortic atherosclerosis and protect the myocardium in high-cholesterol-fed rabbits.