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目的：证实甲硝唑的降脂作用并研究血药浓度与降脂效果的关系。方法：２３例高脂血症患者分为两组，ｐｏ甲硝唑：Ａ组１３例，６００ｍｇｔｉｄ；Ｂ组１０例，４００ｍｇｔｉｄ。两周后测定其血中最低稳态药物浓度（ｃｓｓｍｉｎ）及胆固醇（ＣＨ）、三酰甘油（ＴＧ）值。结果：Ａ、Ｂ两组平均ｃｓｓｍｉｎ分别为（１３．８２±４．１２）ｍｇ·Ｌ－１和（１０．２０±２．５９）ｍｇ·Ｌ－１。１７例降ＴＧ有效和６例无效的患者平均ｃｓｍｉｎ分别为（１３．２７±３．９２）ｍｇ·Ｌ－１和（９．３５±２．２０）ｍｇ·Ｌ－１（Ｐ＜０．０５）；１５例降ＣＨ有效和８例无效的患者ｃｓｓｍｉｎ分别为（１４．０８±３．５９）ｍｇ·Ｌ－１和（８．８０±１．２９）ｍｇ·Ｌ－１（Ｐ＜０．００１）。将２３例患者的ＴＧ和ＣＨ降低率分别与ｃｓｓｍｉｎ作线性回归，相关系数ｒ分别为０．５４９和０．６７５，表明血脂降低程度与ｃｓｓｍｉｎ有高度相关性。结论：血中甲硝唑浓度与用药剂量关系显著且与降脂效果呈正相关关系。
Objective: To confirm the hypolipidemic effect of metronidazole and study the relationship between plasma concentration and lipid-lowering effect. Methods: Twenty-three patients with hyperlipidemia were divided into two groups: po metronidazole: group A, 13 cases, 600 mgtid; group B, 10 cases, 400 mg tid. Two weeks later, the lowest steady-state drug concentration (cssmin), cholesterol (CH) and triglyceride (TG) in blood were determined. Results: The average cssmin of group A and group B were (13.82 ± 4.12) mg · L-1 and (10.20 ± 2.59) mg · L-1.17 (13.27 ± 3.92) mg · L-1 and (9.35 ± 2.20) mg · L-1, respectively (P0.05) The cssmin of patients with invalid cases were (14.08 ± 3.59) mg · L-1 and (8.80 ± 1.29) mg · L-1, respectively (P <0.001). The linear regression of the reduction rate of TG and CH in 23 patients with cssmin respectively, the correlation coefficients r were 0.549 and 0.675, respectively, indicating that there was a high correlation between the degree of lipid lowering and cssmin. Conclusion: There is a significant correlation between the concentration of metronidazole in the blood and the dose of the drug and a positive correlation with the lipid lowering effect.