[目的]观察大黄白及粉联合奥美拉唑治疗应激性溃疡出血的临床疗效。[方法]将入选60例患者随机分为2组,治疗组给予大黄白及粉及奥美拉唑,对照组仅用奥美拉唑。2组疗程均为5 d。[结果]治疗组止血总有效率为93.55%,高于对照组的79.31%(P<0.05),治疗组止血时间为(46.20±1.98)h,与对照组(65.70±3.20)h比较明显缩短(P<0.01)。[结论]大黄白及粉与奥美拉唑联合治疗上消化道应激性溃疡出血具有疗程短、疗效高、不良反应少等优点。 [Objective] To observe the clinical efficacy of rhubarb, white powder and omeprazole in the treatment of stress ulcer bleeding. [Method] The selected 60 patients were randomly divided into two groups, the treatment group was given rhubarb and powder and omeprazole, the control group only omeprazole. The two courses of treatment were 5 d. [Results] The total effective rate of hemostasis in treatment group was 93.55%, which was higher than that in control group (79.31%, P <0.05). The bleeding time in treatment group was (46.20 ± 1.98) h, significantly shorter than that in control group (65.70 ± 3.20) h (P <0.01). [Conclusion] The combined treatment of rhubarb, white powder and omeprazole has the advantages of short course of treatment, high efficacy and few adverse reactions in the treatment of upper gastrointestinal stress ulcer bleeding.