药物的溶解性能实质上是指药物分子从溶解表面向大体积溶液扩散的能力。凡能使溶液中的内在浓度梯度增加的因素均能影响溶解速率。作者以苯妥英作为代表药物,以人血清白蛋白(HSA)和酪蛋白为结合剂,研究了模拟食物对于口服固体剂型溶解性能 The dissolution properties of a drug essentially refer to the ability of drug molecules to diffuse from a dissolved surface to a bulky solution. Any factor that increases the intrinsic concentration gradient in the solution can affect the dissolution rate. Using phenytoin as the representative drug and human serum albumin (HSA) and casein as the binding agents, the authors studied the effect of simulated food on the dissolution properties of oral solid dosage forms