【摘 要】
：
What lurks within the crypt? With more than 200 known causes of ischemic stroke (Saver, 2016), what should be the minimum workup? Many centers offer high-resolution brain imaging and vessel studies, telemetry monitoring for atrial fibrillation (AF), trans
【机 构】
：
Department of Neurology,Morsani College ofMedicine,University of South Florida,Tampa,FL,USA;Departme
论文部分内容阅读
What lurks within the crypt? With more than 200 known causes of ischemic stroke (Saver, 2016), what should be the minimum workup? Many centers offer high-resolution brain imaging and vessel studies, telemetry monitoring for atrial fibrillation (AF), trans-thoracic and trans-esophageal echocardiography, and a panoply of laboratory tests. Nevertheless, the proportion of strokes that are cryptogenic still ranges from 10–40％ (Saver, 2016) which, problematically, includes not only those with an unknown etiology after diagnostic evaluation, but also those with an incomplete workup, as well as those with multiple possible causes (i.e., ipsilateral carotid stenosis with concurrent AF). Such heterogeneity is suboptimal for clinical practice as well as for research, which intends to generate blanket recommendations.
其他文献
MicroRNAs can regulate the function of ion channels in many organs. Based on our previous study we propose that miR-142a-39, which is highly expressed in denervated skeletal muscle, might affect cell excitability through similar mechanisms. In this study,
Exploring the Alzheimer\'s disease neuroepigenome: recent advances and future trends: Alzheimer\'s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmark
The development of amyotrophic lateral sclerosis (ALS) may be related to the abnormal alterations of multiple proteins. Our previous study revealed that the expression of phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4) was decreased in ALS. Howeve
The gastrointestinal track is inhabited by tens of trillions of microorganisms. The gut microbiota is involved in gut motility, nutrient absorption and synthesis of metabolites that influence homeostasis, metabolism and immune function. Given the influenc
Retinal ganglion cell (RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. RGC axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regen
Amyotrophic lateral sclerosis (ALS) is a highly aggressive adult-onset neurodegenerative disease caused by the progressive loss of upper and lower motor neurons. Clinically, it causes irreversible muscle atrophy and spasticity, leading to death due to res
One of the hallmarks of the mature neurons from the central nervous system (CNS) is their inability to grow their axons after an insult. In turn, whenever a neuronal circuit is damaged, either by a neurodegenerative disease or a traumatic injury, the moto
Alzheimer\'s disease (AD) is a progressive and irreversible neurodegenerative disorder that is characterized by memory loss and a decline in activities of daily life. More than 50 million people worldwide are affected by AD, and this number will continu
Oscillating field stimulation(OFS)is a potential method for treating spinal cord injury.Although it has been used in spinal cord injury(SCI)therapy in basic and clinical studies,its underlying mechanism and the correlation between its duration and nerve i
Gene therapy aims to introduce genetic information into a cell-type of interest to replace, correct, silence, or modify defective genes. Gene therapy in its broadest sense can theoretically prevent, halt, or cure any condition that affects mankind. In add