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抗内皮细胞抗体(anti-endothelial cell antibody,AECA)与器官移植后排斥反应的发生有关,而且是除抗HLA抗体外引起排斥反应的主要原因之一,但是检测其移植前后血清水平能否预测排斥反应尚无定论。因此,南京大学医学院金陵医院肾脏病研究所试图通过分析肾移植前后受者血清标本中AECA抗体的变化,来观察其与移植后排斥反应和患者长期预后的关系。该研究共纳入226例肾移植受者:移植前AECA阳性组(n=52)和移植
Anti-endothelial cell antibody (AECA) is associated with rejection after organ transplantation and is one of the major causes of rejection in addition to anti-HLA antibodies. However, whether serum levels before and after transplantation can predict rejection The reaction is inconclusive. Therefore, the Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine attempted to observe the relationship between rejection and long-term prognosis after transplantation by analyzing the changes of AECA antibodies in serum samples of recipients before and after kidney transplantation. A total of 226 renal transplant recipients were enrolled in this study: pre-transplant AECA positive (n = 52) and transplant