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定义与概念治疗相关白血病(Therapy-Related Leuk-emia,TRL)是一种临床病理学新概念。其特点是:在白血病以外的造血或非造血系统恶性肿瘤患者中,继烷化剂等化疗和(或)放疗后,以及非肿瘤性疾患用免疫抑制药物治疗后,经一较长之潜伏期,进入短暂的白血病前期(白前)状态,这时,患者于血细胞减少的同时,伴有显著的血细胞形态学异常。尔后转入全骨髓增生,原始细胞进行性升高,表现出典型的急性白血病临床改变。本病对抗白血病治疗反应差,且生存期比一般急性白血病更为
Definition and Conceptual Therapy Therapy-Related Leuk-emia (TRL) is a new concept of clinical pathology. Its features are: leukemia in patients with hematopoietic or non-hematopoietic malignancies, following alkylating agents and other chemotherapy and (or) radiotherapy, and non-neoplastic disease with immunosuppressive drugs, after a long incubation period, Into the short pre-leukemia (white) state, then, patients with cytopenia, accompanied by significant abnormalities in blood cell morphology. Then transferred to the whole myeloproliferation, primitive cells progressive increase, showing the typical clinical changes in acute leukemia. The disease response to leukemia treatment is poor, and the survival of more than the average acute leukemia more