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目的:观察兰州方加味对头颈部恶性肿瘤放射治疗患者生存质量的影响。方法:将22例头颈部恶性肿瘤患者按信封法分为2组,行调强放射治疗,治疗组10例配合口服兰州方加味,对照组12例配合静脉输注还原型谷胱甘肽钠。采用生命质量量表加头颈部放疗相关症状自行设计的调查问卷,比较2组生存质量量表评分。结果:治疗组角色功能、情绪功能、认知功能、口干、声音变化、面颈部异常、咽口腔疼痛治疗前后比较差异有统计学意义。2组治疗后比较除腹泻、视力下降、社会功能、肢体活动异常方面比较无变化外,其余23个领域改善治疗组均好于对照组,其中认知功能、疲倦、吞咽困难、体质量下降方面比较2组差异有统计学意义。结论:兰州方加味可改善头颈部恶性肿瘤放疗患者生存质量,疗效优于还原型谷胱甘肽钠。
Objective: To observe the effect of Lanzhou Fang Jiawei on the quality of life of patients with radiotherapy of head and neck malignant tumor. Methods: Twenty-two patients with head and neck malignant tumor were divided into two groups according to the envelope method. The patients in the treatment group received 10 doses of Lanzhou decoction. The control group received intravenous reduction of glutathione . Quality of life scale plus head and neck radiotherapy-related symptoms self-designed questionnaire were compared two groups of quality of life scale scores. Results: The role of the treatment group, emotional function, cognitive function, dry mouth, voice changes, face and neck anomalies, pharyngeal cavity pain before and after treatment were statistically significant differences. The other 23 areas were better than the control group, except cognitive function, fatigue, dysphagia, and weight loss, except for diarrhea, decreased visual acuity, social function and abnormal limb activity. The difference between the two groups was statistically significant. Conclusion: Lanzhou Fang Jiawei can improve the quality of life of patients with head and neck cancer radiotherapy, the effect is better than reduced glutathione sodium.