目的探讨思密达对预防危重新生儿消化道出血的效果。方法选择71例危重新生儿随机分为A、B两组:A组为实验组共36例,胃管内注入思密达;B组为对照组,共35例,未使用思密达预防治疗,对两组的病人进行前瞻临床研究。结果实验组的消化道出血发生率8.3%(3/36),对照组的发生率34.3%(12/35),两组差异有统计学意义。结论思密达能有效预防消化道出血的发生,无不良反应。 Objective To explore the effect of Smectite on preventing gastrointestinal bleeding in critically ill newborns. Methods Seventy-one critically ill newborns were randomly divided into A and B groups: A group was 36 in experimental group, Smecta was injected into gastric tube, B group was control group, 35 cases were not treated with Smecta , Prospective clinical study of two groups of patients. Results The incidence of gastrointestinal bleeding was 8.3% (3/36) in the experimental group and 34.3% (12/35) in the control group. The difference between the two groups was statistically significant. Conclusion Smectite can effectively prevent the occurrence of gastrointestinal bleeding without adverse reactions.