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目的探讨奥施康定(盐酸羟考酮控释片)治疗中度癌性疼痛的疗效及不良反应。方法 58例中度癌性疼痛患者中,男性30例,女性28例;平均年龄56.4岁。均为首次服用奥施康定。初始剂量10mg,第12口服。根据疼痛缓解程度调整剂量,评价镇痛效果、KPS评分和不良反应。所有患者均连续用药4周。结果 58例患者用奥施康定最小剂量10mg,每12h口服,最大剂量30mg,第12h口服。完全缓解43例(74.1%),部分缓解15例(25.9%),显效率为100.0%(58/58)。不良反应为便秘6例,恶心呕吐7例,腹胀3例,头晕4例,嗜睡2例。结论奥施康定治疗中度癌性疼痛疗效确切,镇痛效果满意,不良反应轻,服用安全。
Objective To investigate the efficacy and adverse reactions of OxyContin (oxycodone hydrochloride controlled-release tablets) in the treatment of moderately cancerous pain. Methods 58 cases of moderate cancer pain, 30 males and 28 females; mean age 56.4 years old. Oxycodin was taken for the first time. The initial dose of 10mg, 12 oral. Dose adjustment according to the degree of pain relief, evaluation of analgesic effect, KPS score and adverse reactions. All patients were treated for 4 weeks. Results 58 patients were given the lowest dose of Oxycodin 10mg, every 12h orally, the maximum dose of 30mg, 12h orally. Complete remission in 43 cases (74.1%), partial remission in 15 cases (25.9%), markedly effective rate was 100.0% (58/58). Adverse reactions were 6 cases of constipation, nausea and vomiting in 7 cases, abdominal distension in 3 cases, dizziness in 4 cases, drowsiness in 2 cases. Conclusion Oxycodin treatment of moderate cancer pain curative effect is exact, analgesic effect is satisfactory, light adverse reactions, taking safe.