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目的 探讨胰岛素抵抗与小脂蛋白［Ｌｐ（α）］和冠心病的关系。方法 以酶联免疫法对照观察了糖尿病患者胰岛素抵抗组和非胰岛素抵抗组的Ｌｐ（α）及其他脂代谢指标和冠心病的患病率。结果 胰岛素抵抗组和非胰岛素抵抗组的空腹血糖、糖基化血红蛋白和高密度脂蛋白胆固醇无显著差异（Ｐ＞０．０５），而两组总胆固（Ｐ＜０． ０５）、甘油三酯（Ｐ＜０．０５）、低密度脂蛋白胆固醇（Ｐ＜０．０５）有显著差异，特别是Ｌｐ（α）值（Ｐ＜０． ０１）和冠心病的患病率（Ｐ＜０．０１），胰岛素抵抗组较非胰岛素抵抗组极显著升高。结论 在２型糖尿病患者中，胰岛素抵抗可能是导致脂代谢紊乱、Ｌｐ（α）升高和冠心病发生的主要因素之一。
Objective To investigate the relationship between insulin resistance and lipoprotein [Lp (α)] and coronary heart disease. Methods The enzyme linked immunosorbent assay was used to observe the prevalence of Lp (α) and other lipid metabolism indexes and coronary heart disease in insulin resistance and non-insulin resistance groups. Results There was no significant difference in fasting blood glucose, glycosylated hemoglobin and high density lipoprotein cholesterol between insulin resistance group and non-insulin resistance group (P> 0.05), while total cholesterol (P <0.05), triglyceride (P <0.05), low density lipoprotein cholesterol (P <0.05), especially Lp (α) (P <0.01) and the prevalence of coronary heart disease (P <0.05) .01), insulin resistance group than non-insulin resistance group was significantly increased. Conclusion In type 2 diabetic patients, insulin resistance may be one of the major factors that lead to lipid metabolism disorders, elevated Lp (α) and coronary heart disease.