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目的研究甲状腺乳头状癌中Snail蛋白及E-cadherin蛋白的表达及临床意义。方法采用免疫组化S-P法检测64例甲状腺乳头状癌组织和20例甲状腺瘤组织中Snail及E-cadherin蛋白的表达情况,并分析两者与患者临床病理因素之间的关系。结果甲状腺乳头状癌组织中Snail蛋白的阳性率(71.9%)显著高于甲状腺瘤组织(25.0%)(P<0.01),甲状腺乳头状癌组织中E-cadherin蛋白的阳性率(17.2%)显著低于甲状腺瘤组织(85.0%)(P<0.01);Snail及E-cadherin蛋白的表达与TNM分期及有无淋巴结转移密切相关(P均<0.05);甲状腺乳头状癌组织中Snail蛋白与E-cadherin蛋白的表达呈负相关(r=-0.71,P<0.05);Snail蛋白阳性表达者术后1、3、5年生存率明显低于阴性表达者(P均<0.05),E-cadherin蛋白阴性表达者术后1、3、5年生存率明显低于阳性性表达者(P均<0.05)。结论 Snail和E-cadherin蛋白的表达与甲状腺乳头状癌侵袭、转移和预后相关,Snail蛋白表达增强和E-cadherin蛋白表达降低的甲状腺乳头状癌患者预后较差。
Objective To study the expression of Snail protein and E-cadherin protein in papillary thyroid carcinoma and its clinical significance. Methods The expressions of Snail and E-cadherin in 64 cases of thyroid papillary carcinoma and 20 cases of thyroid adenoma were detected by immunohistochemical S-P method. The relationship between them and clinicopathological factors was analyzed. Results The positive rate of Snail protein in papillary thyroid carcinoma (71.9%) was significantly higher than that in thyroid adenoma (25.0%) (P <0.01). The positive rate of E-cadherin protein in papillary thyroid carcinoma was 17.2% (P <0.01). The expressions of Snail and E-cadherin protein were closely related to TNM staging and lymph node metastasis (all P <0.05). The expression of Snail protein in thyroid papillary carcinoma was significantly lower than that in thyroid tissue (85.0% (r = -0.71, P <0.05). The survival rates of one, three and five year postoperatively of Snail protein positive group were significantly lower than those of negative expression group (all P <0.05), while the expression of E-cadherin The 1, 3, 5-year survival rates of patients with protein negative expression were significantly lower than those with positive expression (all P <0.05). Conclusions The expression of Snail and E-cadherin is correlated with the invasion, metastasis and prognosis of papillary thyroid carcinoma. The prognosis of thyroid papillary carcinoma with poor expression of Snail protein and decreased expression of E-cadherin protein is poor.