Vacuum pressurizing casting technique, providing better mould filling and inter-dendritic feeding, can reduce the porosity greatly in cast aluminum alloys, and improve the fatigue properties. The rotary bending fatigue properties of A356-T6 alloys prepared by vacuum pressurizing casting were investigated. The S-N curve and limit strength 90 MPa under fatigue life of 107 cycles were obtained. The analyses on the fatigue fractography and microstructure of specimens showed that the fatigue fracture mainly occurs at the positions with casting defects in the subsurface, especially at porosities regions, which attributed to the crack propagation during the fatigue fracture process. Using the empirical crack propagation law of Pairs-Erdogon, the quantitative relationship among the initial crack size, fatigue life and applied stress was established. The fatigue life decreases with an increase in initial crack size. Two constants in the Pairs-Erdogon equation of aluminum alloy A356-T6 were calculated using the experimental data. Vacuum pressurizing casting technique, providing better mold filling and inter-dendritic feeding, can reduce the porosity greatly in cast aluminum alloys, and improve the fatigue properties. The rotary bending fatigue properties of A356-T6 alloys prepared by vacuum pressurizing casting were investigated. The analyzes on the fatigue fracture and microstructure of specimens showed that the fatigue fracture mainly occurs at the positions with casting defects in the subsurface, especially at porosities regions, which attributed Using the empirical crack propagation law of Pairs-Erdogon, the quantitative relationship among the initial crack size, fatigue life and applied stress was established. The fatigue life decreased with an increase in initial crack size. Two constants in the Pairs-Erdogon equation of aluminum alloy A356-T6 were calc ulated using the experimental data.