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目的:探讨孕期检测促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-AB)、游离甲状腺激素(FT4)及游离三碘甲状腺原氨酸(FT3)对母胎并发症的影响。方法:选取2013年1月~2014年1月在宜昌市第一人民医院进行产前检查的孕中期孕妇200例,检测所有孕妇的TSH、TPO-AB、FT4及FT3水平,同时评估其产时并发症及新生儿并发症情况。结果:200例孕妇中正常61例(对照组),筛查出异常139例(病例组),包括临床甲状腺功能减退30例、亚临床甲状腺功能减退25例、临床甲状腺功能亢进20例、亚临床甲状腺功能亢进34例、单纯TPO-AB阳性30例;病例组贫血、妊娠期糖尿病、妊娠期高血压疾病及产后出血等并发症发生率显著高于对照组,差异具有统计学意义(P<0.05);病例组早产儿、低体重儿、发育迟缓、新生儿呼吸窘迫及死胎等并发症发生率显著高于对照组,差异具有统计学意义(P<0.05)。结论:孕期筛查TSH、TPOAB、FT4及FT3可降低产时并发症及围产儿并发症,值得临床推广。
Objective: To investigate the effects of TSH, TPO-AB, FT4 and FT3 on the complications of pregnancy during pregnancy. Methods: From January 2013 to January 2014, 200 pregnant women of the second trimester at prenatal examination in Yichang First People’s Hospital were enrolled. The levels of TSH, TPO-AB, FT4 and FT3 in all pregnant women were detected. Complications and neonatal complications. Results: Of the 200 pregnant women, 61 were normal (control group), 139 were abnormal cases (case group), including 30 cases of clinical hypothyroidism, 25 cases of subclinical hypothyroidism, 20 cases of clinical hyperthyroidism, Hyperthyroidism in 34 cases, simple TPO-AB positive in 30 cases; case group anemia, gestational diabetes, gestational hypertension and postpartum hemorrhage and other complications was significantly higher than the control group, the difference was statistically significant (P <0.05 ). The incidence of complications such as premature infants, low birth weight children, stunting, neonatal respiratory distress and stillbirth in case group was significantly higher than that in control group (P <0.05). Conclusion: Screening for TSH, TPOAB, FT4 and FT3 in pregnancy can reduce the complications of labor and perinatal complications, which is worthy of clinical promotion.