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目的:探讨新生儿缺氧缺血性脑病(HIE)患儿血清Tau蛋白水平的变化,以及采用复方丹参注射液治疗HIE的过程中Tau水平监测对于疗效监测的临床价值。方法:选择新生儿HIE 60例,随机分为观察组和对照组,对照组采用常规治疗,观察组在常规治疗的基础上采用复方丹参注射液治疗,于治疗前、治疗第3、7、10、14、21、28天分别进行NBNA评分及血清Tau蛋白水平检测,对比两组之间的治疗效果、不同治疗时期Tau检测结果,并分析不同治疗时期Tau检测结果与NBNA评分的相关性。结果:观察组的患儿在症状缓解、惊厥消失、住院病程等方面的指标均明显优于对照组患儿,获得较为明显的治疗效果。治疗前及治疗第3天两组患儿的Tau检测结果无统计学差异(P>0.05),自治疗第3天起至疗程结束日,观察组的Tau均显著低于对照组(P<0.01);Tau浓度与NBNA评分呈现出显著负相关(P<0.05)。结论:Tau水平测定可作为协助判断HIE患儿的脑损伤程度及评价复方丹参注射液治疗效果的临床指标。
Objective: To investigate the changes of serum Tau protein levels in neonates with hypoxic-ischemic encephalopathy (HIE) and the clinical value of Tau monitoring during the treatment of HIE with compound Danshen injection. Methods: Sixty neonates with HIE were selected and randomly divided into observation group and control group. The control group received routine treatment. The observation group was treated with compound Danshen injection on the basis of routine treatment. Before treatment, NBNA score and serum Tau protein level were detected on the 14th, 21st and 28th day respectively. The curative effect between the two groups and the Tau test results at different treatment stages were compared. The correlation between Tau test results and NBNA score was also analyzed. Results: The observation group of children in the symptoms, disappearance of convulsions, hospitalization and other aspects of the indicators were significantly better than the control group of children, access to more obvious therapeutic effect. Before treatment and on the third day of treatment, there was no significant difference in Tau between the two groups (P> 0.05). From the third day to the end of treatment, the Tau in the observation group was significantly lower than that in the control group (P <0.01) ). There was a significant negative correlation between Tau concentration and NBNA score (P <0.05). Conclusion: The determination of Tau levels can be used as a clinical indicator to help determine the extent of brain injury in children with HIE and evaluate the therapeutic effect of compound Danshen injection.