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目的临床观察慢性阻塞性肺疾病患者血清白介素-13水平,探讨慢性阻塞性肺疾病对血清白介素-13的影响。方法入选52例慢性阻塞性肺疾病患者,同期入选39例正常者为对照组,采用双抗体夹心酶联免疫吸附试验法测定入选人群血清白介素-13水平。结果慢性阻塞性肺疾病患者血清白介素-13水平显著高于对照组(P<0.05)。慢性阻塞性肺疾病急性加重期患者血清白介素13水平明显高于稳定期(P<0.05)。两亚组与正常组比较均显著高于对照组(P<0.05)。结论慢性阻塞性肺疾病患者血清白介素-13水平明显增高,且急性期高于稳定期;白介素-13可能参与了慢性阻塞性肺疾病的炎症形成过程,与气道高反应性有关。
Objective To observe the level of serum interleukin-13 in patients with chronic obstructive pulmonary disease (COPD) and investigate the effect of chronic obstructive pulmonary disease on serum interleukin-13. Methods Fifty-two patients with chronic obstructive pulmonary disease were enrolled and 39 normal subjects were enrolled in the same period. Serum levels of interleukin-13 were measured by double antibody sandwich enzyme-linked immunosorbent assay. Results The level of serum interleukin-13 in patients with COPD was significantly higher than that in the control group (P <0.05). The level of serum interleukin-13 in patients with acute exacerbation of chronic obstructive pulmonary disease was significantly higher than that in stable phase (P <0.05). The two subgroups were significantly higher than the control group (P <0.05). Conclusions Interleukin-13 levels in patients with chronic obstructive pulmonary disease are significantly elevated, and are higher than those in acute phase. Interleukin-13 may be involved in the inflammatory process of chronic obstructive pulmonary disease, which is associated with airway hyperresponsiveness.