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新型特异性抗缪勒管激素(AMH)抗体的出现使血清AMH浓度的测量更为精确。AMH由晚期窦前卵泡及小窦状卵泡的颗粒细胞分泌,其可抑制原始卵泡向初级卵泡的转化。女性AMH浓度随着年龄增长而下降,在绝经后无法测量到。相对于其他的生物化学及生物物理的检测指标而言,AMH在评估卵巢储备功能上有许多的优点,AMH的表达并不依赖于下丘脑-垂体-卵巢轴。因此,在整个月经周期中其血清浓度均保持稳定。血清AMH浓度可精确反映卵泡的储备情况,因此被认为是一个预测卵巢储备的灵敏指标。
The emergence of new specific anti-Mueller tube hormone (AMH) antibodies makes the measurement of serum AMH concentration more accurate. AMH is secreted by granulosa cells of late sinusoids and small sinusoid follicles, which inhibit the conversion of primordial follicles to primary follicles. Female AMH concentrations decline with age and can not be measured after menopause. Compared with other biochemical and biophysical indexes, AMH has many advantages in assessing ovarian reserve function. The expression of AMH does not depend on the hypothalamic-pituitary-ovarian axis. Therefore, its serum concentration remained stable throughout the menstrual cycle. Serum AMH concentrations accurately reflect the reserve of follicles and are therefore considered a sensitive indicator of ovarian reserve.