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目的:探讨抗结核药对血液系统的影响,促进临床合理用药。方法:检索1990年1月～2007年4月中国医院数字图书馆(CHKD)期刊全文数据库收载的中文医药卫生期刊,对其报道的抗结核药导致的血液系统异常改变441例作汇总性统计与分析。结果:不良反应涉及15种抗结核药,以利福平、环丙沙星、异烟肼为主,共计211例/次。临床表现以白细胞减少症为多见。结论:临床工作者应掌握引起血液系统不良反应的抗结核药分布规律,安全用药。
Objective: To explore the impact of anti-TB drugs on the blood system and promote clinical rational use of drugs. Methods: The Chinese medical and health periodicals from January 1990 to April 2007 in the full-text database of Chinese Periodicals Digital Library (CHKD) were searched and 441 cases of reported anomalous changes of hematological system caused by anti-TB drugs were collected as summary statistics and analyse. Results: Adverse reactions involving 15 kinds of anti-TB drugs, rifampicin, ciprofloxacin, isoniazid-based, a total of 211 cases / times. Clinical manifestations of leukopenia is more common. Conclusion: Clinical workers should master the distribution of anti-TB drugs that cause adverse reactions of the blood system and safe medication.