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目的检测不同生育能力的男性精液中锌、硒和谷胱甘肽(GSH)含量,探讨抗氧化剂对男性不育的影响。方法对26个正常男性和139名不育症男性精液进行锌、硒浓度和谷胱甘肽水平分析。结果不育组的锌和硒的浓度精浆中的正常对照降低,但是只有锌具有统计学意义。正常对照组的GSHt,GSSG和GSHR的比不育组显著增高。精浆中GSHt浓度和精子活力高度相关。然而,精液GSSG的精子活力相关,与精子畸形率呈负相关;精浆GSHr与精子活力高度相关。结论 GSHt下降和锌、硒不足可以引起的精子质量低下,可能是的男性不育症的重要的生物标志物。
Objective To detect the content of zinc, selenium and glutathione (GSH) in semen of different fertility and to investigate the effect of antioxidants on male infertility. Methods Twenty-six normal male and 139 infertile male semen were analyzed for zinc and selenium concentrations and glutathione levels. Results In the infertile group, the normal control of zinc and selenium concentrations in seminal plasma was reduced, but only zinc was statistically significant. The GSHt, GSSG and GSHR of the normal control group were significantly higher than those of the infertility group. Seminal plasma GSHt concentration and sperm motility are highly correlated. However, sperm motility of sperm GSSG correlated negatively with sperm deformity; seminal plasma GSHr was highly correlated with sperm motility. Conclusions The decline of GSHt and the lack of zinc and selenium may result in low sperm quality and may be an important biomarker of male infertility.