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目的:观察研究采用克拉霉素治疗重度慢性牙周炎的临床治疗效果。方法:从2013年3月到2013年9月在我院进行治疗的中度慢性牙周炎患者中选取94例病例,将患者随机分为观察组与对照组,每组各47例,观察组采用克拉霉素进行治疗,对照组给予甲硝唑进行治疗。观察两组患者的基线、1个月后、3个月后各组病患的SBI牙龈沟出血指数、AL附着能力丧失情况以及PD牙周探诊深度等多项指标的变化情况。结果:观察组与对照组在基线时各临床指标无统计学差异(p>0.05),此外采取克拉霉素治疗的观察组在治疗1个月时,其患者的PD、SBI指标均明显小于对照组(p<0.05),两组AL指标无明显差异(p>0.05)。治疗3个月时,观察组PD、AL指标明显小于对照组(p<0.05),两组SBI无明显差异(p>0.05)结论:采用克拉霉素治疗重度慢性牙周炎具有良好的治疗效果,值得推广。
Objective: To observe the clinical effect of using clarithromycin in the treatment of severe chronic periodontitis. Methods: From March 2013 to September 2013 in our hospital for treatment of moderate chronic periodontitis patients selected 94 cases, the patients were randomly divided into observation group and control group, 47 cases in each group, the observation group The treatment with clarithromycin, the control group were treated with metronidazole. The changes of SBI gingival sulcus bleeding index, loss of AL attachment ability and depth of PD periodontal exploration were observed in two groups at baseline, one month later and three months later. Results: There was no significant difference in the clinical indexes between the observation group and the control group at baseline (p> 0.05). In the observation group treated with clarithromycin at one month, the PD and SBI indexes in the observation group were significantly lower than those in the control group Group (p <0.05), there was no significant difference between the two groups (P> 0.05). At 3 months of treatment, the indexes of PD and AL in the observation group were significantly lower than those in the control group (p <0.05), and there was no significant difference between the two groups (p> 0.05). Conclusion: Clarithromycin treatment of severe chronic periodontitis has good therapeutic effect , Worth promoting.