目的:制备和表征龙血竭PVP固体分散体。方法:以PVP为载体材料,采用共沉淀法制备龙血竭固体分散体;通过红外光谱、差示扫描量热法和X射线衍射法表征其物相特征;以龙血素B含量为指标,评价龙血竭PVP固体分散体的体外溶出性质。结果:当龙血竭与PVP质量比在1∶6.5以上时,龙血竭中多元组分以无定形状态分散在PVP中,以龙血素B为代表成分的溶解度和溶出度明显提高。结论:中药难溶性多元组分可采用共沉淀法制备得到高溶出度的PVP固体分散体。 OBJECTIVE: To prepare and characterize the solid dispersion of PVP. Methods: The solid dispersion of DRX was prepared by coprecipitation method with PVP as carrier material. The phase characterization was characterized by infrared spectroscopy, differential scanning calorimetry and X-ray diffraction. To evaluate the in vitro dissolution properties of PVP solid dispersions from DRG. Results: When the mass ratio of DRG to PVP was above 1: 6.5, the multivariate components of DRG were dispersed in PVP in an amorphous state, and the solubility and dissolution of DRB were significantly increased. Conclusion: PVP solid dispersions with high dissolution rate can be prepared by coprecipitation method.