XJ 16 0病毒是我国首次分离的辛德毕斯病毒 ,在对其全基因组核苷酸序列测定的基础上 ,对病毒基因组序列、病毒同源性和病毒系统进化等进行了较为详细的分析 ,结果表明 :XJ 16 0病毒具有典型的甲病毒属辛德毕斯病毒的序列特征。该病毒nsp3蛋白基因中有 11处缺失及两处插入 (45 17～ 5 485 ) ,涉及 90个核苷酸。核苷酸序列的系统进化分析表明 ,XJ 16 0病毒属于辛德毕斯病毒欧洲 /非洲亚组。病毒全基因组核苷酸序列进化分析显示 ,XJ 16 0病毒是一株新的甲病毒或辛德毕斯病毒的新亚型。 The XJ160 virus is the first Sindbis virus isolated in China. Based on the genome-wide nucleotide sequence analysis, the virus genome sequence, virus homology and virus system evolution were analyzed in detail. The results showed that : The XJ160 virus has the sequence signature of the typical alphavirus Sindbis virus. There are eleven deletions and two insertions (4517-5485) in the nsp3 protein of the virus, involving 90 nucleotides. Phylogenetic analysis of the nucleotide sequences showed that the XJ160 virus belongs to the Sindbis virus Europe / Africa subgroup. Genome-wide nucleotide sequence analysis of the virus showed that the XJ160 virus is a new alphavirus or a new subtype of Sindbis virus.