论文部分内容阅读
人类营养中微量元素的重要意义正愈来愈受到重视。已确定了大量的锌-金属酶,其中包括碱性磷酸酶、碳酸酐酶、羧肽酶和醇脱氢酶。锌可调节某些在核酸代谢中起主要作用的酶的活性,如DNA-和RNA-聚合酶以及胸苷激酶。认为锌缺乏的至关紧要的损伤是一种尚未阐明的信使RNA代谢异常,从而导致DNA和蛋白质合成减少,细胞分裂能力下降。这就不难想象,亲代雌性动物缺锌会导致胎儿生长迟缓和先天性畸形。锌缺乏可由摄入量减少、吸收障碍或排泄增加所致。已证明,中东出现的青春期营养性侏儒症和明显
The importance of trace elements in human nutrition is receiving more and more attention. A number of zinc-metalloenzymes have been identified, including alkaline phosphatase, carbonic anhydrase, carboxypeptidase and alcohol dehydrogenase. Zinc modulates the activity of certain enzymes that play a major role in nucleic acid metabolism, such as DNA- and RNA-polymerase, as well as thymidine kinase. It is thought that the crucial damage of zinc deficiency is an unspecified messenger RNA metabolic abnormality, which leads to the decrease of DNA and protein synthesis and the decrease of cell division ability. It is not hard to imagine that the lack of zinc in the parental female leads to slow fetal growth and congenital malformations. Zinc deficiency can be caused by reduced intake, increased absorption or increased excretion. Proved adolescent nutritional dwarfism and apparent in the Middle East