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目的:探讨高海拔地区病毒性脑炎(VE)的病原学特点。方法:分析2002年—2004年我院VE病原学资料,病原学诊断方法采用酶联免疫吸附法(ELISA)和间接酶联法检测脑脊液(CSF)中病毒IgM抗体,选择阳性标本122例。结果:122例阳性标本中柯萨奇病毒27.05%,居首位,流感病毒20.49%,副流感病毒14.75%,EB病毒13.93%,单纯疱疹病毒Ⅰ型9.84%。结论:柯萨奇病毒是本地区VE的首位病原,流感、副流感病毒、EB病毒、疱疹病毒Ⅰ型依次次之。各地交流、探索、改进实验方法有助于丰富病原学资料。
Objective: To investigate the etiological characteristics of viral encephalitis (VE) in high altitude areas. Methods: The data of etiological VE in our hospital from 2002 to 2004 were analyzed. The etiological diagnosis method was used to detect IgM antibodies in cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay (ELISA) and indirect enzyme-linked immunosorbent assay. 122 positive samples were selected. Results: Among 122 positive samples, Coxsackievirus 27.05%, first place, influenza virus 20.49%, parainfluenza virus 14.75%, Epstein-Barr virus 13.93% and herpes simplex virus type I 9.84%. Conclusion: Coxsackie virus is the first pathogen of VE in the region, with influenza, parainfluenza virus, Epstein-Barr virus and herpes simplex virus type Ⅰ in turn. Exchanging, exploring and improving experimental methods all over the world can enrich the etiology.