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目的探讨注射液雷替曲塞治疗老年晚期结直肠癌的临床效果。方法选择不同期老年晚期结直肠癌患者中分别随机选择50例为对照组、观察组两组均利用L-OHP,对照组:联合甲酰四氢叶酸(LV)和5-氟尿嘧啶注射液;观察组:联合注射用雷替曲塞,研究疗效。结果两组近期治疗总有效率比较差异有统计学意义(P<0.05);治疗毒性反应情况比较差异无统计学意义(P>0.05);观察组的中位疾病进展时间(TTP)为8.3个月,显著高于对照组的5.2个月,差异有统计学意义(P<0.05)。结论雷替曲塞治疗老年晚期结直肠癌可以获得良好的临床效果。
Objective To investigate the clinical efficacy of injection raltitrexed in the treatment of elderly patients with advanced colorectal cancer. Methods 50 cases of elderly patients with advanced colorectal cancer were randomly selected as the control group, the observation group were used L-OHP, the control group: combined leucovorin (LV) and 5-fluorouracil injection; observed Group: Combined injection of raltitrexed, study efficacy. Results The total effective rate of two groups was statistically significant difference (P <0.05). There was no significant difference in the treatment response between the two groups (P> 0.05). The median time to progression (TTP) in the observation group was 8.3 Month, significantly higher than the control group of 5.2 months, the difference was statistically significant (P <0.05). Conclusion raltitrexed in elderly patients with advanced colorectal cancer can get good clinical results.