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目的 :研究系统性红斑狼疮 (SLE)血清IL - 18和可溶性sFas/可溶性sFas配体 (sFas/sFasL)的变化及相关性。方法 :采用ELISA检测 4 5例SLE患者和 18例正常人群血清中IL - 18,sFas及sFasL水平。结果 :SLE各组sFas/sFasL水平与正常对照组比较 ,差异具有非常显著性意义 (P <0 .0 1) ,其中相对活动期sFas较相对缓解期明显增高 (P <0 .0 1) ,sFasL无明显差异 (P >0 .0 5 )。IL - 18水平在SLE患者显著高于正常对照组 (P<0 .0 1) ,相对活动期患者较正常对照组和相对缓解期患者差异显著 (P <0 .0 1) ,而相对静止期患者血清水平则与正常对照组无明显差异 (P >0 .0 5 )。SLE患者和相对活动期患者血清IL - 18水平与sFas增高呈显著的正相关 (P <0 .0 1)。结论 :IL - 18,sFas及sFasL在SLE发病中有一定意义 ,IL - 18的变化与sFas表达具有相关性
Objective: To study the changes and correlations of serum IL - 18 and soluble sFas / sFas / sFasL in systemic lupus erythematosus (SLE). Methods: Serum levels of IL - 18, sFas and sFasL in 45 SLE patients and 18 normal controls were detected by ELISA. Results: The levels of sFas / sFasL in SLE group were significantly higher than those in normal control group (P <0.01), and sFas in relative active stage was significantly higher than that in relative remission stage (P <0.01) sFasL no significant difference (P> 0.05). The level of IL - 18 in patients with SLE was significantly higher than that in controls (P <0.01). The relative activity of patients with IL - 18 was significantly higher than that in controls and patients with relative remission (P <0.01) Serum levels of patients with no significant difference compared with the normal control group (P> 0.05). Serum levels of IL - 18 in patients with SLE and those with relative activity were significantly positively correlated with increased sFas (P <0.01). Conclusion: IL - 18, sFas and sFasL have some significance in the pathogenesis of SLE. The change of IL - 18 is correlated with the expression of sFas