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用双抗体夹心ＥＬＩＳＡ方法动态监测４６例恶性淋巴瘤（ＭＬ）患者脑脊液（ＣＳＦ）中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平变化。发现ＭＬ患者脑脊液中ｓＩＬ－２Ｒ比正常人显著升高（Ｐ＜０．００１），且６例有中枢神经系统（ＣＮＳ）浸润者ｓＩＬ－２Ｒ与无ＣＮＳ浸润者相比有显著性差异（Ｐ＜０．０１）；而治疗达ＣＲ或ＰＲ后ｓＩＬ－２Ｒ显著降低（Ｐ＜０．０５），与正常人者相比Ｐ＞０．０５，脑脊液ｓＩＬ－２Ｒ水平与血清中ｓＩＬ－２Ｒ水平无显著相关性。认为动态监测ＭＬ患者脑脊液ｓＩＬ－２Ｒ水平有助于估价病变严重程度、ＣＮＳ有无浸润及疗效评定
The level of soluble interleukin 2 receptor (sIL-2R) in cerebrospinal fluid (CSF) of 46 patients with malignant lymphoma (ML) was dynamically monitored by double antibody sandwich ELISA. sIL-2R levels in cerebrospinal fluid of ML patients were significantly higher than those in normal controls (P<0.001), and sIL-2R in 6 patients with central nervous system (CNS) infiltration was significantly different from those without CNS infiltration (P). <0.01); sIL-2R was significantly lower after treatment with CR or PR (P<0.05), P>0.05 compared with normal controls, sIL-2R levels in cerebrospinal fluid, and sIL-2R levels in serum. No significant correlation. It is believed that the dynamic monitoring of sIL-2R levels in cerebrospinal fluid in patients with ML is helpful in assessing the severity of disease, the presence or absence of CNS infiltration, and efficacy assessment.