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目的观察前列地尔治疗短暂性脑缺血发作的临床疗效。方法选择2011年1月—2014年5月在天津市武清区人民医院就诊的短暂性脑缺血患者100例,随机分为对照组和治疗组,每组各50例。对照组采用常规治疗,治疗组在常规治疗基础上静脉滴注前列地尔注射液,2 m L/次加生理盐水10 m L直接入小壶静脉滴注。两组均连续治疗15 d。观察两组的临床疗效,同时比较治疗前后两组凝血指标、血液黏度指数和血流动力学参数的变化。结果治疗后,对照组和治疗组的总有效率分别为82.0%、94.0%,两组总有效率比较差异有统计学意义(P<0.05)。治疗前后两组血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)差异均无统计学意义。治疗后,两组全血黏度、血浆黏度、纤维蛋白原、脑血管阻力(R)均较治疗前显著降低,两组最大血流速度(Vmax)、最小血流速度(Vmin)、平均血流速度(Vmean)、平均血流量(Qmean)均较治疗前显著升高,同组治疗前后差异有统计学意义(P<0.05),且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论前列地尔治疗短暂性脑缺血发作具有较好的临床疗效,无明显副作用,具有高效、安全等优点,值得临床推广应用。
Objective To observe the clinical efficacy of alprostadil in the treatment of transient ischemic attack. Methods From January 2011 to May 2014, 100 patients with transient ischemic attack in Wuqing District People’s Hospital of Tianjin were randomly divided into control group and treatment group, 50 cases in each group. The control group was treated with routine treatment. The treatment group was treated with alprostadil by intravenous drip, and the group received intravenous infusion of 10 m L / 2 m L / normal saline directly into the small pot. Both groups were treated for 15 days. The clinical efficacy of the two groups were observed. The changes of coagulation index, blood viscosity index and hemodynamic parameters were compared between the two groups before and after treatment. Results After treatment, the total effective rates of the control group and the treatment group were 82.0% and 94.0%, respectively. The total effective rate was significantly different between the two groups (P <0.05). Before and after treatment, the platelet count (PLT), prothrombin time (PT), partial prothrombin time (APTT) showed no significant difference. After treatment, the whole blood viscosity, plasma viscosity, fibrinogen and cerebrovascular resistance (R) in both groups were significantly lower than those before treatment. The maximal blood flow velocity (Vmax), minimum blood flow velocity (Vmin) Vmean and Qmean were significantly higher than those before treatment, the difference was statistically significant (P <0.05) before and after treatment in the same group, and the improvement of these indexes in the treatment group was better than that in the control group. The two groups The difference was statistically significant (P <0.05). Conclusion Alprostadil treatment of transient ischemic attack has better clinical efficacy, no obvious side effects, with high efficiency, safety and other advantages, it is worthy of clinical application.