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用压力引起大鼠尾部机械性损伤时，脑电图呈去同步化表现，将５－ＨＴ_２受体阻断剂ｃｉｎａｎｓｅｒｉｎ（４ｍｇ／ｋｇ）静脉注射于年轻成年鼠可阻断由伤害性刺激所致的脑电去同步化现象，而对老龄大鼠的脑电反应元阻断作用；将肾上腺素α_（１Ａ－１Ｄ）及α_（２Ｂ，２Ｃ）受体阻断剂Ｐｒａｚｏｓｉｎ（４ｍｇ／ｋｇ）静脉注射于老龄大鼠可阻断由伤害性刺激引起的脑电去同步化现象，但对年轻成年大鼠的脑电反应无阻断作用。此结果可能是随着年龄的老化５－ＨＴ受体的敏感性降低，而肾上腺素受体的亲合力升高；在年轻成年大鼠两类受体的敏感性则相反，５－ＨＴ受体的敏感性较高，而肾上腺素受体的亲合力较低。该结果对不同年龄患者镇痛药物的应用可能有指导意义。
Electroencephalogram showed desynchronization when pressure was used to induce mechanical damage to the tail of rats. Intravenous injection of cinanserin (4 mg / kg), a 5-HT 2 receptor blocker, in young adult mice blocked the effects of noxious stimuli (1 mg / kg) and Prazosin (4 mg / kg), a blocker of α2 (2B, 2C) adrenergic receptor, Injection into the aged rats blocked the desynchronization of EEG induced by noxious stimuli, but did not block the EEG response in young adult rats. This result may be that the aging 5-HT receptor sensitivity decreases with age, and the adrenergic receptor affinity increases; in young adult rats, the sensitivity of the two types of receptors is opposite, the 5-HT receptor The sensitivity is higher, while the adrenergic receptor affinity is lower. This result may be instructive for the use of analgesic drugs in patients of different ages.