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为探讨胰岛素生长因子 - I (IGF- I)与妊高征 (PIH)合并胎儿宫内发育迟缓 (IUGR)的病因学关系 ,选择 31例 PIH合并 IUGR作为研究组 ,同期住院 PIH34例作为对照组 ,于临产前抽取孕母肘静脉血及新生儿出生时脐静脉血 ,通过放射免疫方法测定 IGF- I的水平。结果 :(1 ) IUGR母血清 IGF- I水平为 39.96± 7.1 7ng/ ml,低于脐血清 IGF- I水平 78.2 2± 1 6.1 4 ng/ ml,两者相比差异显著 (P<0 .0 1 )。(2 )对照组母血清 IGF- I水平为 48.89± 6.46ng/ml,高于脐血清 IGF- I水平 2 7.0 2± 2 .68ng/ ml,有显著性差异 (P<0 .0 1 )。 (3)两组母血清相比 :IUGR组母血清中IGF- I的水平低于对照组 (P<0 .0 1 )有显著性差异 ;两组脐血清相比 :IUGR组脐血 IGF- I的水平明显高于对照组 ,差异有显著性 (P<0 .0 1 )。提示 PIH孕妇血清中的 ICF- I与 IUGR的发生有关 ,与出生体重呈正相关 ,是导致妊高征 IUGR的重要原因之一
To investigate the etiology of insulin-like growth factor-I (IGF-I) and pregnancy-induced hypertension (PIH) associated with intrauterine growth retardation (IUGR), 31 PIH patients with IUGR were selected as study group and 34 hospitalized PIH patients as control group , Umbilical venous blood taken from pregnant elbow before birth and neonatal birth, and the level of IGF-I by radioimmunoassay. Results: (1) The IGF-I level of IUGR maternal serum was 39.96 ± 7.1 7ng / ml, which was lower than that of umbilical serum IGF-I of 78.2 ± 6.1144ng / ml, the difference was significant (P <0. 0 1 ). (2) The serum IGF-I level of the control group was 48.89 ± 6.46ng / ml, which was significantly higher than that of the umbilical serum IGF-I level of 2 7.02 ± 2.68ng / ml (P <0.01). (3) The serum levels of IGF-I in maternal serum of IUGR group were significantly lower than that of control group (P <0.01). Compared with IUGR group, the levels of IGF- I levels were significantly higher than the control group, the difference was significant (P <0.01). It is suggested that ICF-I in serum of PIH is related to the occurrence of IUGR and positively correlated with birth weight, which is one of the important reasons leading to IUGR