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目的 :血管系统存在的血红素氧合酶 (hemeoxygenase,HO)可催化血红素分解产生CO。本实验通过建立相关的运动模型 ,观察不同运动负荷对SD大鼠主动脉平滑肌HO -CO系统的影响。方法 :检测主动脉平滑肌HO活性、CO生成量。结果 :经每天 45分钟、90分钟、1 5 0分钟几种负荷训练 ,9周后 ,大鼠主动脉平滑肌HO酶的活性与对照组相比分别增加了 5 3 78%、81 48%、1 2 0 66% ,CO生成则分别提高 3 1 98%、83 1 2 %、1 2 1 90 % ,而且不同负荷组之间比较有显著性差异 ;并发现HO -CO的激活具有运动负荷的依赖性。结论 :长期运动可以激发主动脉平滑肌中的HO -CO的活性 ,运动对HO -CO系统的诱导高度敏感 ,随着运动负荷的增加 ,HO -CO的活性可相应上调。
OBJECTIVE: Hemeoxygenase (HO) present in vascular system can catalyze heme decomposition to produce CO. This experiment through the establishment of the relevant exercise model to observe the effects of different exercise load on the aortic smooth muscle HO-CO system in SD rats. Methods: HO activity and CO production of aortic smooth muscle were measured. Results: Compared with the control group, the activities of HO enzyme in rat aortic smooth muscle increased by 57%, 81%, 48% and 1% respectively after several times of training at 45 minutes, 90 minutes and 150 minutes. 2 0 66% and CO 3 1 98%, 83 1 2% and 1 2 1 90%, respectively, and there was a significant difference between different load groups. It was also found that activation of HO -CO was dependent on exercise load Sex. CONCLUSION: Long-term exercise can stimulate the activity of HO-CO in aortic smooth muscle. Exercise is highly sensitive to the induction of HO-CO system. With the increase of exercise load, the activity of HO-CO can be increased accordingly.