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前列环素前列环素的发现,充分揭示了前列腺素内过氧化物生物化学的微妙性质。前列环素是迄今已发现的、最强的,血小板聚集的天然抑制剂,也是一种高效的血管扩张剂,这些性质正好和凝血素A_2的性质相反,可是两种物质具有相同的生化前体,即前列腺素环内过氧化物PGG_2和PGH_2。在心血管系统中,凝血素A_2的生物合成似乎是集中在血小板中,而前列环素是在血管壁中产生的。GormanR R等人已经证明,这两种化合物是通过调节环腺苷酸(cAMP)的产生而发挥它们的作
The discovery of prostacyclin prostacyclin fully reveals the subtle properties of prostaglandin endoperoxide biochemistry. Prostacyclin is by far the most potent, natural inhibitor of platelet aggregation and is also a potent vasodilator, which is exactly the opposite in nature to that of prothrombin A 2. However, both substances have the same biochemical precursors , Namely prostaglandin ring peroxide PGG_2 and PGH_2. In the cardiovascular system, the biosynthesis of prothrombin A 2 seems to be concentrated in platelets, whereas prostacyclin is produced in the blood vessel wall. GormanR R et al. Have demonstrated that these two compounds exert their action by modulating the production of cyclic adenosine monophosphate (cAMP)