论文部分内容阅读
目的探讨肝细胞癌（ＨＣＣ）患者癌组织与癌旁组织中雄、雌激素受体的变化．方法用葡聚糖包裹活性炭吸附法检测２１例ＨＣＣ患者的癌组织和癌旁组织中雄激素受体（ＡＲ）和雌激素受体（ＥＲ），同时测量７例男性肝硬变患者肝组织中的ＡＲ和ＥＲ．结果癌组织中ＡＲ阳性率（７１４％）显著高于癌旁组织（３１３％）（Ｐ＜００１）及硬变肝组织（Ｐ＜００５）中的ＡＲ阳性率（２８６％），而ＥＲ含量均无显著差异（Ｐ＞００５）．结论ＡＲ表达的增加与肝细胞的癌变有关，部分ＨＣＣ具有雄激素依赖性，为ＨＣＣ可能的内分泌治疗提供分子生物学方面的理论依据．
Objective To investigate the changes of the male and estrogen receptors in cancer tissues and adjacent tissues of hepatocellular carcinoma (HCC). Methods The androgen receptor (AR) and estrogen receptor (ER) were detected in cancer tissues and paracancerous tissues of 21 patients with HCC by dextran-coated activated carbon adsorption method. At the same time, the liver tissues of 7 male cirrhosis patients were measured. AR and ER. Results The positive rate of AR in cancer tissue (71.4%) was significantly higher than that in para-cancer tissue (31. 3%) (P <0. 01) and in the hardened liver tissue (P <0. 05). 28 6%), but there was no significant difference in ER content (P>005). Conclusion The increase of AR expression is related to the carcinogenesis of hepatocytes. Some HCCs are androgen dependent and provide theoretical basis for the possible endocrine therapy of HCC in molecular biology.