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首次报道了以β-溴代四乙酰半乳糖和N-乙酰基-5-溴-4-氯-3-羟基吲哚为原料,经过7步化学反应,合成了用于检测白色念珠菌的N-乙酰胺基半乳糖苷酶底物5-溴-4-氯吲哚-3-基-N-乙酰基-β-D-氨基半乳糖苷,并通过核磁、质谱以及生物测定确证其结构。
For the first time, it was reported that β-bromo-tetraacetylgalactose and N-acetyl-5-bromo-4-chloro-3-oxindole were used as raw materials to synthesize N -acetamido galactosidase substrate 5-Bromo-4-chloroindol-3-yl-N-acetyl-β-D-galactosamine and confirmed its structure by NMR, MS and bioassay.