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阿司匹林具有退热、消炎、止痛和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的物质的量比为1∶1和1∶2,制备阿司匹林和腐植酸固态络合物。阿司匹林和腐植酸分子间相互作用通过差示扫描量热法(DSC)、X射线衍射(XRD)、傅里叶变换红外光谱学法(FT-IR)和扫描电子显微镜法(SEM)进行研究。用这些技术能清晰表明固态包合络合物的结构。对物质的量比为1∶2冻干络合物研究表明,阿司匹林的稳定性和溶出率显著提高。优选的冻干阿司匹林与腐植酸(1∶2)络合物对抑制鼠爪水肿和抗溃疡作用测得的最低值(0.63±0.10)与单纯的阿司匹林相比,有明显的降低,证明用其治疗具有非常显著的抗炎作用(P<0.05)。
Aspirin has antipyretic, anti-inflammatory, analgesic and anti-platelet aggregation. Acetylsalicylic acid molecules contain a carboxyl group and an ester group. Ester groups are easily hydrolyzed, resulting in lower potency and side effects on the human body. The purpose of this study was to prepare aspirin and humic acid solid complexes using the lyophilization technique and the solvent evaporation technique at a 1: 1 and 1: 2 ratio of material to material. Interaction between aspirin and humic acid molecules was investigated by differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). These techniques clearly show the structure of the solid inclusion complex. A 1: 2 ratio of substance to the lyophilized complex showed that the stability and dissolution rate of aspirin were significantly increased. The lowest value (0.63 ± 0.10) of the preferred lyophilized aspirin and humic acid (1: 2) complexes for the inhibition of rat paw edema and antiulcer activity was significantly lower than that of pure aspirin alone Treatment has a very significant anti-inflammatory effect (P <0.05).