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药物的多晶现象是影响药品质量与临床疗效的重要因素之一,直接关系到用药安全。无论是对于创新药物还是仿制药,药物晶型研究都极为重要。近年来,药物晶型研究也越来越引起我国制药企业及药物学家的重视。本文应用专利地图技术,对药物晶型这一技术领域近30年的专利申请情况、技术生命周期、申请人国别、国外竞争者以及技术发展重点药物品种等方面进行了详细的统计分析。了解我国药物晶型的发展、现状以及当前的竞争格局,有助于把握我国药物晶型领域未来技术发展方向,为药物晶型开发相关的专利战略规划与产业政策制定提供参考;以及帮助我国科研机构和企业在药物晶型的竞争中提升研发起点。
The polycrystalline phenomenon of drugs is one of the important factors that affect the quality and clinical efficacy of drugs, which is directly related to the safety of drugs. Whether for innovative drugs or generic drugs, drug crystal research is extremely important. In recent years, the study of crystalline polymorphism has drawn more and more attention from pharmaceutical companies and pharmacologists in our country. In this paper, a detailed statistical analysis of the patent application, the life cycle of the technology, the country of the applicant, the foreign competitors, and the key drug varieties of the technology development for the past 30 years in the field of crystalline form of the drug has been carried out using the patent map technology. Understanding the development, current situation and current competition pattern of crystal form in our country can help to grasp the future development direction of the pharmaceutical crystal form in our country, and provide reference for the strategic planning and industrial policy formulation of pharmaceutical crystal development. Institutions and companies to enhance the starting point for research and development in the competition of drug crystal form.