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雷帕霉素(rapamycin,Rap)是从吸水链霉菌(streptomyces hygroscopicus)中分离出来的一种大环内酯类抗生素[1],临床主要应用于真菌感染及肿瘤的治疗,它既是经典的自噬促进剂,同时也是针对哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)特异性的抑制剂。近年研究发现,Rap还具有较好的脑保护、神经营养及抗衰老作用,可能与其对神经细胞凋亡和自噬的影响相关。1凋亡与自噬凋亡即Ⅰ型程序性细胞死亡,是指在一定生理、病理条件下,
Rapamycin (Rap) is a macrolide antibiotic isolated from Streptomyces hygroscopicus [1]. It is mainly used in the treatment of fungal infections and tumors. It is both classic It is also a specific inhibitor of mammalian target of rapamycin (mTOR). Recent studies have found that Rap also has better brain protection, neurotrophic and anti-aging effects, may be related to its impact on nerve cell apoptosis and autophagy. Apoptosis and apoptosis of autophagy that type Ⅰ programmed cell death, refers to a certain physiological and pathological conditions,