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目的探讨粉尘螨口含滴剂治疗变应性哮喘的疗效。方法对符合变应性哮喘诊断标准并且粉尘螨变应原皮肤点刺试验呈阳性的患者用粉尘螨口含滴剂治疗,从低剂量起逐步递增,比较治疗前后第一秒用力呼气肺活量占预计值的百分比(FEV1%)、最大呼气流量(PEF)、血嗜酸性粒细胞计数、痰嗜酸性粒细胞计数、粉尘满的特异性IgE(sIgE)。结果治疗后FEV1%、PEF比治疗前增加(P<0.05),血液、痰液嗜酸性粒细胞及血sIgE比治疗前下降(P<0.01)。结论粉尘螨口含滴剂免疫治疗对变应性哮喘具有良好的效果,能显著改善哮喘患者的肺功能。
Objective To investigate the efficacy of dust mite oral drops in the treatment of allergic asthma. Methods Patients with positive diagnostic criteria for allergic asthma and dermatophagous allergens skin prick tests were treated with drops of dust and mite mouth drops, gradually increasing from low dose, comparing forced expiratory volume in the first second before and after treatment Percent predicted (FEV1%), maximum expiratory flow (PEF), blood eosinophil count, sputum eosinophil count, dust-full specific IgE (sIgE). Results After treatment, FEV1% and PEF were higher than those before treatment (P <0.05), blood, sputum eosinophils and blood sIgE were lower than before treatment (P <0.01). Conclusion Dust mite oral drops immunotherapy has a good effect on allergic asthma, can significantly improve lung function in patients with asthma.