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目的探讨影响上海市金山区张堰镇地区晚期血吸虫患者生存时间的危险因素,为临床治疗和选择药物提供参考依据。方法对张堰镇地区2006年11月-2012年12月纳入健康管理的137例晚期血吸虫患者病例进行回顾性分析。结果通过统计分析得出,晚期血吸虫患者合并的最常见并发症为高血压(53.12%);该地区晚期血吸虫病最常见的临床分型是巨脾型(70.80%);行脾切除术相比不切除脾脏的患者,平均生存时间多2年;血吸虫患者发病初期采用血防846治疗能使患者具有较长的生存时间(55年);肝脏质地和腹水量的大小,是加速晚期血吸虫患者死亡的主要危险因素。结论用血防846治疗血吸虫病可延长患者生存时间;晚期血吸虫患者应严格控制血压,对于肝脏硬度和腹水量较大者,需严格进行治疗。
Objective To investigate the risk factors affecting the survival time of patients with advanced schistosomiasis in Zhangyan Town, Jinshan District, Shanghai, so as to provide reference for clinical treatment and selection of drugs. Methods A retrospective analysis of 137 patients with advanced schistosomiasis in health management from November 2006 to December 2012 in Zhangyan town was conducted. Results The statistical analysis showed that the most common complication of advanced schistosomiasis was hypertension (53.12%). The most common clinical classification of advanced schistosomiasis in this area was splenomegaly (70.80%). Compared with splenectomy The average survival time of patients without splenectomy was 2 years. In the early stage of schistosomiasis, blood-based 846 therapy could prolong the survival time of patients (55 years). The liver texture and the amount of ascites were accelerated in patients with advanced schistosomiasis The main risk factors. Conclusion Treatment of schistosomiasis by blood-borne 846 can prolong the survival time of patients. Patients with advanced schistosomiasis should control the blood pressure strictly. For patients with severe liver cirrhosis and ascites, strict treatment is required.