胃癌是日本最常见的恶性肿瘤,许多流行病学调查发现高盐饮食与胃癌高度相关,而与其它器官的肿瘤无相关性。作者曾报道食盐对大鼠胃癌的启动和促进均有增强作用。为了阐明膳食中的食盐是否能选择性地引起胃粘膜脂质过氧化从而影响细胞增殖,作者进行了本次研究。实验比较了氯化钠对大鼠一些器官脂质过氧化的影响,还用环氧化酶抑制剂消炎痛研究了其特异性。 Gastric cancer is the most common malignancy in Japan. Many epidemiological studies have found that high-salt diet is highly correlated with gastric cancer but not with other organs. The authors have reported salt on the promotion and promotion of gastric cancer have enhanced role. In order to clarify whether dietary salt can selectively cause gastric mucosal lipid peroxidation and thus affect cell proliferation, the authors conducted this study. The effects of sodium chloride on lipid peroxidation in some organs of rats were compared. The specificity of the cyclooxygenase inhibitor indomethacin was also studied.