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目的 探讨溶栓治疗对急性心肌梗死后左室结构和功能的影响。方法 对 36例首发急性心肌梗死患者于梗死后 4周和 12周进行超声心动图观察。分别测定左室舒张末期容积指数 (LVEDVI)、左室收缩末期容积指数 (LVESVI)、射血分数 (EF) ,作为反映左室结构和功能变化的指标。结果 急性心肌梗死后LVEDVI、LVESVI均明显增高 (分别为P <0 0 1,P <0 0 5 )。 4周和 12周检查发现 ,溶栓组LVEDVI、LVESVI无明显差异 (分别P>0 0 5 ,P >0 0 5 ) ,EF值明显增大 (P <0 0 5 ) ;未溶栓组LVEDVI、LVESVI明显增大 (分别为P <0 0 5 ,P <0 0 5 ) ,EF值无明显变化 (P >0 0 5 ) ;对 4周和 12周的检查结果作组间比较发现 ,溶栓组LVEDVI、LVESVI均小于未溶栓组 (P <0 0 5 ) ,EF值溶栓组高于未溶栓组 (P <0 0 5 )。结论 溶栓治疗能有效地抑制急性心肌梗死后左室重构 ,改善心功能。
Objective To investigate the effect of thrombolytic therapy on left ventricular structure and function after acute myocardial infarction. Methods Thirty-six patients with acute myocardial infarction were observed echocardiography at 4 and 12 weeks after infarction. Left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI) and ejection fraction (EF) were measured respectively, which were used as indexes to reflect changes of left ventricular structure and function. Results LVEDVI and LVESVI were significantly increased after acute myocardial infarction (P <0.01, P <0.05). LVEDVI and LVESVI in thrombolytic group had no significant difference (P> 0.05, P> 0.05), EF value increased significantly at 4 and 12 weeks (P <0 05). LVEDVI , LVESVI increased significantly (P <0 05, P <0 05 respectively), EF had no significant change (P 0 05); 4 and 12 weeks of the test results were compared between groups found that dissolution The values of LVEDVI and LVESVI in the embolization group were all lower than those in the non-thrombolytic group (P <0.05). Conclusion Thrombolytic therapy can effectively inhibit left ventricular remodeling and improve cardiac function after acute myocardial infarction.