急性心肌梗死时,挽救濒死心肌的最有效方法是再灌注治疗,但大量研究证实再灌注治疗又有其不利的一面,即再灌注损伤。为此,如何保护缺血心肌免于再灌注损伤就成为重要的研究内容。1986年,Murry等首次报道了缺血预适应现象(ischemic preconditioning IPC),即一次或多次短暂缺血后恢复血流再灌注,心肌对随后出现更长时间的严重缺血产生 In the case of acute myocardial infarction, the most effective way to save the dying myocardium is reperfusion therapy, but a large number of studies have shown that reperfusion therapy has its downside, namely reperfusion injury. To this end, how to protect ischemic myocardium from reperfusion injury has become an important research content. In 1986, Murry et al reported for the first time ischemic preconditioning (IPC), in which one or more episodes of transient ischemia resumed blood flow reperfusion, followed by myocardial ischemia followed by a longer period of severe ischemia